Everest Biotech/Erlotinib HCl 2g/1100150023/2g
来自 :
发布时间：2025-01-10
| Molecular Weight: | 429.9 g/mol |
| Molecular Formula: | C22H23N3O4•HCl |
| CAS Number : | 183319-69-9 |
| Solubility: | Soluble in DMSO at 18 mg/mL with warming; very poorly soluble in ethanol |
| Purity: | ≥99% |
| Storage: | -20C |
| Applications: | Anti-neoplastic |
Material Safety Data SheetDate:Oct 23,20151. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name: Erlotinib HClCatalog No:1100150013,1100150023,1100150053,1100150103,11001502531.2 Relevant identified uses of the substance or mixture and uses advised againstFor research use only.1.3 Details of the supplier of the safety data sheetCompany:Eton Bioscience IncTollFree:1-800-758-1630Tel:1-800-758-1630Fax:1-800-507-29121.4 Emergency telephone number1-800-758-16302. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureAcute toxicity: oral, Category 4Acute toxicity:dermal,Categort 4Acute toxicity:inhalation(Dusts/Mists),Category 4Skin corrosion/irritation,Category 2Serious eye damage/eye irritation,Category 2ASpecific target organ toxicity, Category 32.2 GHS Label elements, including precautionary statementsPictogram | Signal Word Precautionary Statement P264 P301+P312 P501 | Warning Wash skin thoroughly after handling IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Dispose of contents/container to an approved waste disposal plant |
2.3 Other hazardsNone3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesMolecular Formula:C₂₉H₃₁N₇O.CH₄SO₃Molecular Weight:429.9g/molCAS No:183319-69-94. FIRST AID MEASURES4.1 Description of first aid measuresEye contactCheck for and remove contact lenses and flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physicianSkin ContactFlush with copious amounts of water; remove contaminated clothing and shoes; call a physicianInhalationIf inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respirationIngestionIf swallowed, wash out mouth with copious amounts of water; call a physician4.2 Most important symptoms and effects, both acute and delayedNo information available4.3 Indication of any immediate medical attention and special treatment needed.No information available5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaWater spray, carbon dioxide, dry chemical powder or foam 5.2 Special hazards arising from the substance or mixtureNo information available5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions,protective equipment and emergency proceduresUse full personal protective equipment. Evacuate personnel to safe areas.6.2 Environmental precautionsPrevent further leakage or spillage. Prevent product from entering drain.6.3 Methods and material for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 137. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid skin/eye contact. Use protective equipment as needed. Wash contaminated clothing before reuse.7.2 Conditions for safe storage,including any incompatibilitiesKeep container tightly closed in a cool,well-vented place. Store at -20˚C.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL INFORMATION8.1 Control ParametersThis product contains no hazardous materials with occupational exposure limits.8.2 Exposure controlsEngineering controlsProvide shower and eye wash stationPersonal protective equipment | Eye Protection | Wear safety goggles |
| Skin Protection | Wear protective clothing |
| Hand Protection | Wear protective gloves |
| Respiratory protection | Wear NIOSH/MSHA approved respirators |
9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical properties | Appearance | Solid |
| pH | No data available |
| Melting point | No data available |
| Freezing point | No data available |
| Boiling point | No data available |
| Density | No data available |
| Water solubility | Very poorly soluble |
9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1ReactivityNo data available10.2Chemical stabilityStable under recommended storage conditions.10.3Possibility of hazardous reactionsNo data available.10.4Conditions to avoidProtect from light and heat10.5Incompatible materialsstrong oxidizing agents10.6Hazardous decomposition productsThermal decomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides11. TOXICOLOGICAL INFORMATION11.1Information on toxicological effectsToxicological effects on this product have not been thoroughly studied.12. ECOLOGICAL INFORMATION12.1ToxicityAvoid release into environment12.2Persistence and degradabilityNo data available12.3.Bioaccumulative potentialNo data available12.4Mobility in soilNo data available12.5Results of PBT and vPvB assessmentNo data available12.6Other adverse effectsNo data available13. DISPOSAL INFORMATION13.1Waste treatment methodsDispose in accordance with local, state, and federal regulations.14. TRANSPORT INFORMATIONDOT:Proper shipping name: noneNon-Hazardous for transport: this substance is considered to be non-hazardous for transportIATA:Proper shipping name: noneNon-Hazardous for transport: this substance is considered to be non-hazardous for transportIMDG:Proper shipping name: noneNon-Hazardous for transport: this substance is considered to be non-hazardous for transport15. REGULATORY INFORMATIONEU Risk and Safety phrases:R22: Harmful if swallowedS22: Do not breathe dustS24/25: Avoid contact with skin and eyesS26: In case of contact with eyes, rinse immediately with plenty of water and seek medical adviceS28:after contact with skin, wash immediately with plenty of waterS36/37/39:Wear suitable protective clothing,gloves and eye/face protection16. OTHER INFORMATIONThe information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information. Eton Bioscience Inc. shall not be held liable for any damages or other consequences resulting from handling or from contact with the above product.
Wang Y, Yuan JL, Zhang YT, Ma JJ, Xu P, et al. (2013) Inhibition of Both EGFR and IGF1R Sensitized Prostate Cancer Cells to Radiation by Synergistic Suppression of DNA Homologous Recombination Repair. PLoS ONE 8(8): e68784. doi:10.1371/journal.pone.0068784本文链接： http://etonbio.immuno-online.com/view-1462749767.html
