- Description
- Product Info
- Shipping and Storage
- Downloads
- References
Description
Fluocinolone is a synthetic hydrocortisone derivative that exhibits anti-inflammatory and anti-pruritic activities. Fluocinolone is a corticosteroid that is clinically used to treat ocular inflammation. In dental pulp cells, fluocinolone downregulates expression of pro-inflammatory cytokines and upregulates expression of PPARγ.
Product Info
67-73-2 |
≥98% |
C24H30F2O6 |
452.49 |
(6α,11β,16α)-6,9-Difluoro-11,21-dihydroxy-16,17- [(91-methylethylidene)bis(oxy)]-pregna-1,4-diene- 3,20-dione |
Coriphate; Dermalar; Fluonid; Fluvean; Jellin; Synalar; Synemol; Synsac |
265-266°C |
Slightly soluble in water ( |
White/Almost White crystalline powder |
Shipping and Storage
Ambient |
Ambient |
Downloads
F4582 MSDS PDF |
F4582 Info Sheet PDF |
References
Cunha-Vaz J, Ashton P, Iezzi R, et al. Sustained Delivery Fluocinolone Acetonide Vitreous Implants: Long-Term Benefit in Patients with Chronic Diabetic Macular Edema. Ophthalmology. 2014 Jun 13. [Epub ahead of print]. PMID: 24935282.
Liu Z, Jiang T, Wang X, et al. Fluocinolone acetonide partially restores the mineralization of LPS-stimulated dental pulp cells through inhibition of NF-κB pathway and activation of AP-1 pathway. Br J Pharmacol. 2013 Nov;170(6):1262-71. PMID: 24024985.
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