- Description
- Product Info
- Shipping and Storage
- Downloads
- References
Description
Mitoxantrone is an anthracenedione that exhibits immunosuppressive and anticancer chemotherapeutic activities. Mitoxantrone is clinically used to treat multiple sclerosis (MS), breast cancer, non-Hodgkin’s lymphoma, acute myeloid leukemia (AML), and acute lymphoblastic leukemia (ALL). Mitoxantrone acts as an intercalator, cross-linking and forming complexes in DNA, inhibiting DNA synthesis; it also inhibits Pim-1 kinase.
Product Info
70476-82-3 |
≥98% |
C22H28N4O6 • 2HCl |
517.41 |
1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl) amino]- ethyl] amino]-9,10-anthracenedione dihydrochloride |
1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione;dihydrochloride |
Mitoxantrone hydrochloride; Novantrone |
160-162°C |
Soluble in water. |
Blue/Black Crystalline Powder |
Shipping and Storage
Ambient |
Ambient |
Downloads
M3379 MSDS PDF |
M3379 Info Sheet PDF |
References
Pendleton M, Lindsey RH Jr, Felix CA, et al. Topoisomerase II and leukemia. Ann N Y Acad Sci. 2014 Mar;1310:98-110. PMID: 24495080.
Wan X, Zhang W, Li L, et al. A new target for an old drug: identifying mitoxantrone as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling. J Med Chem. 2013 Mar 28;56(6):2619-29. PMID: 23442188.
Parker C, Waters R, Leighton C, et al. Effect of mitoxantrone on outcome of children with first relapse of acute lymphoblastic leukaemia (ALL R3): an open-label randomised trial. Lancet. 2010 Dec 11;376(9757):2009-17. PMID: 21131038.
Mazerski J, Martelli S, Borowski E. The geometry of intercalation complex of antitumor mitoxantrone and ametantrone with DNA: molecular dynamics simulations. Acta Biochim Pol. 1998;45(1):1-11. PMID: 9701490.
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